Discovery and structural optimization of 3-O-β-Chacotriosyl betulonic acid saponins as potent fusion inhibitors of Omicron virus infectionsArticle Published on 2023-02-012023-07-11 Journal: Bioorganic chemistry [Category] COVID19(2023년), [키워드] Betulonic acid derivatives membrane fusion omicron Structure–activity relationships. [DOI] 10.1016/j.bioorg.2022.106316 PMC 바로가기
Lancemaside A from Codonopsis lanceolata: Studies on Antiviral Activity and Mechanism of Action against SARS-CoV-2 and Its Variants of ConcernArticle Published on 2022-12-202023-07-10 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), [키워드] COVID-19 lancemaside A membrane fusion omicron SARS-CoV-2 triterpenoid saponin. [DOI] 10.1128/aac.01201-22 PMC 바로가기
Astersaponin I from Aster koraiensis is a natural viral fusion blocker that inhibits the infection of SARS-CoV-2 variants and syncytium formationArticle Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] Aster koraiensis Astersaponin I COVID-19 membrane fusion SARS-CoV-2 variants Syncytium. [DOI] 10.1016/j.antiviral.2022.105428 PMC 바로가기
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin furin. generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronavirusesArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antiviral drug Biological functions cell entry characterization characterized Coronavirus-2 D614G domains FIVE functional glycosylated help less membrane fusion mutant N-glycosylation O-glycosylation Recombinant spike protein S proteins S1 protein S1 subunit SARS-CoV-2 Sialylation spike Spike protein Spike proteins Vaccine β-coronavirus β-coronavirus β-coronavirus. β-CoV β-CoVs [DOI] 10.1016/j.aca.2022.340394 PMC 바로가기
Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?Article Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accumulated aging atopic atopic dermatitis bat bat coronaviruses cause Cell China conditions coronavirus COVID-19 Diabetes Mellitus disease Diseases enzyme epidemiological data Europe Exacerbation help highest homology Host Human humans hypertension infect Inflammation Inflammatory inflammatory condition mechanism membrane fusion Middle East occurred poor prognosis promote psoriasis pulmonary disease receptor ACE2 SARS-CoV-2 skin skin. TMPRSS viral infection virus [DOI] 10.3390/ijms232012260 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants variants. Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike proteinArticle Published on 2022-10-042022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome affected Antiviral assays coronavirus coronavirus disease epitope glycoprotein heptad repeat host cell HR2 include inhibit inhibitor interact interfere less membrane membrane fusion Modification monoclonal antibody Mutation N-terminal offer peptide Peptide Inhibitors peptide. peptides performed Protein Receptor binding domain Region related viruses S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Support target the S protein the SARS-CoV-2 the spike protein therapy Vaccine variants viral entry viral membrane viral spike virus infection [DOI] 10.1073/pnas.2210990119 PMC 바로가기
Synthesis and structure-activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2SARS-CoV-2에 대한 사포닌계 막융합 억제제의 합성 및 구조-활성 관계 연구Article Published on 2022-10-012022-09-11 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent Antiviral agents antiviral efficacy Cell cell entry Cell fusion Complex molecule Complex molecules synthesis component Compound coronavirus coronavirus variants COVID-19 Critical derivative develop Effectiveness endosomal experiment fusion Glucose host cell host cell membranes inhibit inhibited inhibitor inhibitors membrane fusion protease Saponin saponins Saponins. SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 variant SARS-CoV-2 variants Serine sugar synthesis the SARS-CoV-2 transmembrane [DOI] 10.1016/j.bioorg.2022.105985 PMC 바로가기 [Article Type] Article